Version 5.4
Homo sapiens Protein: MINA
Summary
InnateDB Protein IDBP-484692.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MINA
Protein Name MYC induced nuclear antigen
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000424955
InnateDB Gene IDBG-46577 (MINA)
Protein Structure
UniProt Annotation
Function Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269PubMed:12091391, ECO:0000269PubMed:14695334, ECO:0000269PubMed:15534111, ECO:0000269PubMed:15819408, ECO:0000269PubMed:15897898, ECO:0000269PubMed:17317935, ECO:0000269PubMed:19502796, ECO:0000269PubMed:23103944}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12091391, ECO:0000269PubMed:15819408}. Nucleus, nucleolus {ECO:0000269PubMed:12091391, ECO:0000269PubMed:15819408}.
Disease Associations
Tissue Specificity Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. {ECO:0000269PubMed:14695334, ECO:0000269PubMed:15534111, ECO:0000269PubMed:15897898, ECO:0000269PubMed:19502796}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0042254 ribosome biogenesis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003347 JmjC domain
PFAM PF02373
PF08007
PRINTS
PIRSF
SMART SM00558
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IUF8
PhosphoSite PhosphoSite-Q8IUF8
TrEMBL D6RCB6
UniProt Splice Variant
Entrez Gene 84864
UniGene Hs.742206
RefSeq
HUGO HGNC:19441
OMIM 612049
CCDS
HPRD 17575
IMGT
EMBL AB083189 AB083190 AB083191 AB083192 AB083193 AC026100 AC110491 AK027299 AY302110 AY390536 AY456380 BC014928 CH471052 CR627479 DQ453796
GenPept AAH14928 AAP59421 AAR21572 AAR27293 ABE28016 BAB55024 BAC16358 BAC16359 BAC16360 BAC16361 BAC16537 CAH10679 EAW79872 EAW79873

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca