InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL15

Summary

InnateDB Protein

IDBP-484722.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL15

Protein Name

interleukin 15

Synonyms

IL-15;

Species

Homo sapiens

Ensembl Protein

ENSP00000422271

InnateDB Gene

IDBG-39028 (IL15)

Protein Structure

UniProt Annotation

Function

Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.

Subcellular Localization

Isoform IL15-S48AA: Secreted.Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Disease Associations

Tissue Specificity

Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15- S21AA is preferentially expressed in tissues such as testis and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005126	cytokine receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0032740	positive regulation of interleukin-17 production
GO:0034105	positive regulation of tissue remodeling
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane