Version 5.4
Homo sapiens Protein: KCNK2
Summary
InnateDB Protein IDBP-484747.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK2
Protein Name potassium channel, subfamily K, member 2
Synonyms hTREK-1c; hTREK-1e; K2p2.1; TPKC1; TREK; TREK-1; TREK1;
Species Homo sapiens
Ensembl Protein ENSP00000420203
InnateDB Gene IDBG-106654 (KCNK2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0015271 outward rectifier potassium channel activity
GO:0019870 potassium channel inhibitor activity
GO:0022841 potassium ion leak channel activity
Biological Process
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR003976 Two pore domain potassium channel, TREK
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
PFAM PF00520
PF07885
PRINTS PR01499
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95069
PhosphoSite PhosphoSite-O95069
TrEMBL C9JXY2
UniProt Splice Variant
Entrez Gene 3776
UniGene Hs.497745
RefSeq XP_006711370
HUGO HGNC:6277
OMIM 603219
CCDS
HPRD
IMGT
EMBL AC092804 AC099675 AF004711 AF129399 AF171068 AK291483 AK315249 AL583830 AY552980 AY552981 BC069462 BC101693 BC101695 BC143586 CH471100 EF165334 EF165335
GenPept AAD01203 AAD47569 AAF89743 AAH69462 AAI01694 AAI01696 AAI43587 AAT49015 AAT49016 ABM47413 ABM47414 BAF84172 BAG37671 EAW93347 EAW93349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca