InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TAF1L

Summary

InnateDB Protein

IDBP-484842.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF1L

Protein Name

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418379

InnateDB Gene

IDBG-56102 (TAF1L)

Protein Structure

UniProt Annotation

Function

May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced. {ECO:0000269PubMed:12217962}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Testis specific, expressed apparently in germ cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004402	histone acetyltransferase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0017025	TBP-class protein binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0006352	DNA-templated transcription, initiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007140	male meiosis
GO:0016573	histone acetylation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005575	cellular_component
GO:0005669	transcription factor TFIID complex

Protein Structure and Domains

PDB ID

InterPro

IPR001487 Bromodomain
IPR009067 TAFII-230 TBP-binding
IPR011177 Transcription initiation factor TFIID subunit 1, animal
IPR022591 Transcription initiation factor TFIID subunit 1, domain of unknown function

PFAM

PF00439
PF09247
PF12157

PRINTS

PR00503

PIRSF

PIRSF003047

SMART

SM00297

TIGRFAMs

Post-translational Modifications

Modification

Cross-References