Version 5.4
Homo sapiens Protein: TCF25
Summary
InnateDB Protein IDBP-48518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF25
Protein Name transcription factor 25 (basic helix-loop-helix)
Synonyms hKIAA1049; Hulp1; NULP1; PRO2620;
Species Homo sapiens
Ensembl Protein ENSP00000263346
InnateDB Gene IDBG-48516 (TCF25)
Protein Structure
UniProt Annotation
Function May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development. {ECO:0000269PubMed:16574069}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16574069, ECO:0000269PubMed:18068114}. Note=Some staining in the cytosol.
Disease Associations
Tissue Specificity In the embryo, widely expressed with highest levels in brain. In the adult, highest expression is found in the heart. {ECO:0000269PubMed:16574069}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR006994 Transcription factor 25
PFAM PF04910
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BQ70
PhosphoSite PhosphoSite-Q9BQ70
TrEMBL
UniProt Splice Variant
Entrez Gene 22980
UniGene
RefSeq NP_055787
HUGO HGNC:29181
OMIM 612326
CCDS CCDS10987
HPRD 13830
IMGT
EMBL AB028972 AF322111 BC000959 BC009349 BC011884 DQ321703
GenPept AAG50276 AAH00959 AAH09349 AAH11884 ABC55265 BAA83001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca