InnateDB Protein
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IDBP-485328.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KLF6
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Protein Name
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Kruppel-like factor 6
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Synonyms
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BCD1; CBA1; COPEB; CPBP; GBF; PAC1; ST12; ZF9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000419079
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InnateDB Gene
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IDBG-46758 (KLF6)
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Protein Structure
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Function |
Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development. {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269PubMed:15824733}. Note=The disease is caused by mutations affecting the gene represented in this entry.Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269PubMed:11752579}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
30
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
9
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007087
Zinc finger, C2H2
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PFAM |
PF00096
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99612
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PhosphoSite |
PhosphoSite-Q99612
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1316
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UniGene |
Hs.713327
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RefSeq |
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HUGO |
HGNC:2235
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OMIM |
602053
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CCDS |
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HPRD |
03632
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IMGT |
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EMBL |
AB017493
AF001461
AF284036
AK293259
AK316596
AL450322
AL513303
BC000311
BT006778
CH471072
U44975
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GenPept |
AAC23699
AAC39929
AAH00311
AAM73548
AAP35424
BAA33050
BAG38183
BAG56791
CAH71010
CAH71011
CAH74049
CAH74050
EAW86477
EAW86479
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