InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SCML2

Summary

InnateDB Protein

IDBP-48534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCML2

Protein Name

sex comb on midleg-like 2 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000251900

InnateDB Gene

IDBG-48532 (SCML2)

Protein Structure

UniProt Annotation

Function

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary. {ECO:0000269PubMed:10331946}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	19 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009653	anatomical structure morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0031519	PcG protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR004092 Mbt repeat
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
IPR021987 Protein of unknown function DUF3588

PFAM

PF02820
PF00536
PF12140

PRINTS

PIRSF

SMART

SM00454
SM00561

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UQR0