InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIDINS220

Summary

InnateDB Protein

IDBP-485344.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIDINS220

Protein Name

kinase D-interacting substrate, 220kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000418974

InnateDB Gene

IDBG-27177 (KIDINS220)

Protein Structure

UniProt Annotation

Function

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)- induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress- induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. {ECO:0000250, ECO:0000269PubMed:18089783}.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Late endosome {ECO:0000250}. Note=Localized at late endosome before or after nerve growth factor (NGF) stimulation.

Disease Associations

Tissue Specificity

Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines. {ECO:0000269PubMed:18089783}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0010976	positive regulation of neuron projection development
GO:0016482	cytoplasmic transport
GO:0038180	nerve growth factor signaling pathway
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005770	late endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR011646 KAP P-loop
IPR013761 Sterile alpha motif/pointed domain
IPR020683 Ankyrin repeat-containing domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00023
PF13606
PF07693
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt