InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGMB

Summary

InnateDB Protein

IDBP-485386.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGMB

Protein Name

RGM domain family, member B

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000423256

InnateDB Gene

IDBG-35165 (RGMB)

Protein Structure

UniProt Annotation

Function

Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. {ECO:0000250, ECO:0000269PubMed:19324014}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Membrane raft {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042802	identical protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0030509	BMP signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated