InnateDB Protein
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IDBP-48661.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ASIC3
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Protein Name
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amiloride-sensitive cation channel 3
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Synonyms
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ACCN3; DRASIC; SLNAC1; TNaC1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000350600
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InnateDB Gene
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IDBG-244835 (ASIC3)
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Protein Structure
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Function |
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269PubMed:9744806, ECO:0000269PubMed:9886053}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. {ECO:0000269PubMed:9571199, ECO:0000269PubMed:9886053}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001873
Na+ channel, amiloride-sensitive
IPR004724
Epithelial sodium channel
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PFAM |
PF00858
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PRINTS |
PR01078
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UHC3
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PhosphoSite |
PhosphoSite-Q9UHC3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9311
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UniGene |
Hs.647113
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RefSeq |
NP_064718
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HUGO |
HGNC:101
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OMIM |
611741
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CCDS |
CCDS5914
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HPRD |
10626
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IMGT |
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EMBL |
AB010575
AB209421
AF057711
AF095897
AF195024
AF195025
AK313926
CH471173
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GenPept |
AAC62935
AAC64188
AAF19817
AAF19818
BAA25897
BAD92658
BAG36647
EAW54052
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