Version 5.4
Homo sapiens Gene: ASIC3
Summary
InnateDB Gene IDBG-244835.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIC3
Gene Name acid-sensing (proton-gated) ion channel 3
Synonyms ACCN3; DRASIC; SLNAC1; TNaC1
Species Homo sapiens
Ensembl Gene ENSG00000213199
Encoded Proteins
IDBP-48661
amiloride-sensitive cation channel 3
IDBP-48663
amiloride-sensitive cation channel 3
IDBP-48669
amiloride-sensitive cation channel 3
IDBP-48671
amiloride-sensitive cation channel 3
IDBP-485297
amiloride-sensitive cation channel 3
IDBP-479257
amiloride-sensitive cation channel 3
IDBP-479441
amiloride-sensitive cation channel 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:151048292-151052756
Strand Forward strand
Band q36.1
Transcripts
ENST00000357922 ENSP00000350600
ENST00000377904 ENSP00000367136
ENST00000349064 ENSP00000344838
ENST00000297512 ENSP00000297512
ENST00000468325 ENSP00000418605
ENST00000474135
ENST00000485929 ENSP00000420371
ENST00000490540 ENSP00000418361
ENST00000498105
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0030165 PDZ domain binding
GO:0042931 enterobactin transporter activity
Biological Process
GO:0006810 transport
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0007165 signal transduction
GO:0007600 sensory perception
GO:0009408 response to heat
GO:0009612 response to mechanical stimulus
GO:0010447 response to acidity
GO:0034220 ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042930 enterobactin transport
GO:0050907 detection of chemical stimulus involved in sensory perception
GO:0050915 sensory perception of sour taste
GO:0050961 detection of temperature stimulus involved in sensory perception
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0050968 detection of chemical stimulus involved in sensory perception of pain
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038276
View Gene Order
ENSBTAG00000007762
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9UHC3
TrEMBL H7C4W0
UniProt Splice Variant
Entrez Gene 9311
UniGene Hs.647113
RefSeq NM_004769 NM_020321 NM_020322
HUGO HGNC:101
OMIM 611741
CCDS CCDS5914 CCDS5915 CCDS5916
HPRD
IMGT
EMBL AB010575 AB209421 AC010973 AF057711 AF095897 AF195024 AF195025 AK313926 CH471173
GenPept AAC62935 AAC64188 AAF19817 AAF19818 BAA25897 BAD92658 BAG36647 EAW54052
RNA Seq Atlas 9311

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca