InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASIC3

Summary

InnateDB Protein

IDBP-48669.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASIC3

Protein Name

amiloride-sensitive cation channel 3

Synonyms

ACCN3; DRASIC; SLNAC1; TNaC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000344838

InnateDB Gene

IDBG-244835 (ASIC3)

Protein Structure

UniProt Annotation

Function

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. {ECO:0000269PubMed:9744806, ECO:0000269PubMed:9886053}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cell surface expression may be stabilized by interaction with LIN7B and cytoplasmic retention by interaction with DLG4. In part cytoplasmic in cochlea cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed by sensory neurons. Strongly expressed in brain, spinal chord, lung, lymph nodes, kidney, pituitary, heart and testis. {ECO:0000269PubMed:9571199, ECO:0000269PubMed:9886053}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005261	cation channel activity
GO:0005272	sodium channel activity
GO:0015280	ligand-gated sodium channel activity

Biological Process

GO:0006810	transport
GO:0006814	sodium ion transport
GO:0007165	signal transduction
GO:0007600	sensory perception
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050915	sensory perception of sour taste
GO:0055085	transmembrane transport