InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PHLDA1

Summary

InnateDB Protein

IDBP-48880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PHLDA1

Protein Name

pleckstrin homology-like domain, family A, member 1

Synonyms

DT1P1B11; PHRIP; TDAG51;

Species

Homo sapiens

Ensembl Protein

ENSP00000266671

InnateDB Gene

IDBG-48878 (PHLDA1)

Protein Structure

UniProt Annotation

Function

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. {ECO:0000269PubMed:11369516, ECO:0000269PubMed:12738777}.

Subcellular Localization

Cytoplasm. Cytoplasmic vesicle membrane. Nucleus, nucleolus. Note=Colocalizes with intracellular vesicles.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in pancreas. Strongly expressed by benign melanocytic nevi, and progressively reduced expressed in primary and metastatic melanomas (at protein level). {ECO:0000269PubMed:12384558, ECO:0000269PubMed:12738777}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0021879	forebrain neuron differentiation
GO:0043065	positive regulation of apoptotic process
GO:0045210	FasL biosynthetic process