InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLEKHH2

Summary

InnateDB Protein

IDBP-48933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHH2

Protein Name

pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000282406

InnateDB Gene

IDBG-48929 (PLEKHH2)

Protein Structure

UniProt Annotation

Function

In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22832517}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:22832517}. Cell membrane {ECO:0000269PubMed:22832517}; Peripheral membrane protein {ECO:0000269PubMed:22832517}; Cytoplasmic side {ECO:0000269PubMed:22832517}. Cell projection, lamellipodium {ECO:0000269PubMed:22832517}. Note=Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent on PI3K.

Disease Associations

Tissue Specificity

Kidney. Reduced expression in patients with focal segmental glomerulosclerosis. {ECO:0000269PubMed:22832517}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0030835

negative regulation of actin filament depolymerization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0030864	cortical actin cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000299 FERM domain
IPR000857 MyTH4 domain
IPR001849 Pleckstrin homology domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR029071 Ubiquitin-related domain

PFAM

PF00784
PF00169
PF00373

PRINTS

PIRSF

SMART

SM00139
SM00233
SM00295

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8IVE3