InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRA1

Summary

InnateDB Protein

IDBP-48936.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRA1

Protein Name

steroid receptor RNA activator 1

Synonyms

pp7684; SRA; SRAP; STRAA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000337513

InnateDB Gene

IDBG-241049 (SRA1)

Protein Structure

UniProt Annotation

Function

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand- dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis. {ECO:0000269PubMed:10199399, ECO:0000269PubMed:12943696, ECO:0000269PubMed:14517287, ECO:0000269PubMed:15147866, ECO:0000269PubMed:15351741}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12565891}. Cytoplasm {ECO:0000269PubMed:12565891}.

Disease Associations

Tissue Specificity

Highly expressed in liver and skeletal muscle and to a lesser extent in brain. Also expressed in both normal and tumorigenic breast epithelial cell lines. Significantly up- regulated in human tumors of the breast, ovary, and uterus. {ECO:0000269PubMed:10199399, ECO:0000269PubMed:12565891, ECO:0000269PubMed:14517287}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	42 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	7 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0010861	thyroid hormone receptor activator activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0008283	cell proliferation
GO:0030154	cell differentiation
GO:0042981	regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:2000273	positive regulation of receptor activity

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015630	microtubule cytoskeleton
GO:0030529	ribonucleoprotein complex
GO:0031252	cell leading edge
GO:0045171	intercellular bridge