Version 5.4
Homo sapiens Gene: SRA1
Summary
InnateDB Gene IDBG-241049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRA1
Gene Name steroid receptor RNA activator 1
Synonyms pp7684; SRA; SRAP; STRAA1
Species Homo sapiens
Ensembl Gene ENSG00000213523
Encoded Proteins
IDBP-48936
steroid receptor RNA activator 1
IDBP-812284
steroid receptor RNA activator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Both long non-coding and protein-coding RNAs are transcribed from this gene, and they represent alternatively spliced transcript variants. This gene was initially defined as a non-coding RNA, which is a coactivator for several nuclear receptors (NRs) and is associated with breast cancer. It has now been found that this gene is involved in the regulation of many NR and non-NR activities, including metabolism, adipogenesis and chromatin organization. The long non-coding RNA transcripts interact with a variety of proteins, including the protein encoded by this gene. The encoded protein acts as a transcriptional repressor by binding to the non-coding RNA. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140537340-140558310
Strand Reverse strand
Band q31.3
Transcripts
ENST00000336283 ENSP00000337513
ENST00000523259
ENST00000520427
ENST00000602657 ENSP00000473378
ENST00000602775
ENST00000602875
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 7 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0010861 thyroid hormone receptor activator activity
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0008283 cell proliferation
GO:0030154 cell differentiation
GO:0042981 regulation of apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:2000273 positive regulation of receptor activity
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0030529 ribonucleoprotein complex
GO:0031252 cell leading edge
GO:0045171 intercellular bridge
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006050
View Gene Order
ENSBTAG00000001449
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.653135
RefSeq NM_001035235
HUGO
OMIM
CCDS CCDS34245
HPRD 18716
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca