InnateDB Protein
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IDBP-48966.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GAS8
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Protein Name
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growth arrest-specific 8
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Synonyms
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GAS11;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000268699
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InnateDB Gene
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IDBG-48962 (GAS8)
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Protein Structure
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Function |
Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in the heart, skeletal muscle, pancreas and liver. Weakly or not expressed in brain, placenta, lung and kidney. {ECO:0000269PubMed:9790751}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95995
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PhosphoSite |
PhosphoSite-O95995
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TrEMBL |
H3BUA7
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UniProt Splice Variant |
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Entrez Gene |
2622
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UniGene |
Hs.739124
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RefSeq |
NP_001472
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HUGO |
HGNC:4166
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OMIM |
605178
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CCDS |
CCDS10992
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HPRD |
05533
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IMGT |
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EMBL |
AC133919
AF050068
AF050069
AF050070
AF050071
AF050072
AF050073
AF050074
AF050075
AF050076
AF050077
AF050078
AF050079
AK297857
AK315261
BC104785
BC112121
CH471184
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GenPept |
AAC69518
AAC69519
AAI04786
AAI12122
BAG37678
BAH12677
EAW66659
EAW66661
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