InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: E2F7

Summary

InnateDB Protein

IDBP-49115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F7

Protein Name

E2F transcription factor 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323246

InnateDB Gene

IDBG-49113 (E2F7)

Protein Structure

UniProt Annotation

Function

Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'- TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation. {ECO:0000269PubMed:14633988, ECO:0000269PubMed:15133492, ECO:0000269PubMed:18202719, ECO:0000269PubMed:19223542, ECO:0000269PubMed:21248772, ECO:0000269PubMed:22802528, ECO:0000269PubMed:22802529, ECO:0000269PubMed:22903062}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15133492}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001890	placenta development
GO:0002040	sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0032466	negative regulation of cytokinesis
GO:0032877	positive regulation of DNA endoreduplication
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060707	trophoblast giant cell differentiation
GO:0060718	chorionic trophoblast cell differentiation
GO:0070365	hepatocyte differentiation
GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle