Version 5.4
Homo sapiens Gene: E2F7
Summary
InnateDB Gene IDBG-49113.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F7
Gene Name E2F transcription factor 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165891
Encoded Proteins
IDBP-49115
E2F transcription factor 7
IDBP-380503
E2F transcription factor 7
IDBP-588328
E2F transcription factor 7
IDBP-586457
E2F transcription factor 7
IDBP-588232
E2F transcription factor 7
IDBP-592928
E2F transcription factor 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:77021247-77065580
Strand Reverse strand
Band q21.2
Transcripts
ENST00000322886 ENSP00000323246
ENST00000416496 ENSP00000393639
ENST00000550669 ENSP00000448245
ENST00000552907 ENSP00000447963
ENST00000551058 ENSP00000449284
ENST00000551558
ENST00000547316 ENSP00000449033
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0002040 sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0032466 negative regulation of cytokinesis
GO:0032877 positive regulation of DNA endoreduplication
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060707 trophoblast giant cell differentiation
GO:0060718 chorionic trophoblast cell differentiation
GO:0070365 hepatocyte differentiation
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020185
View Gene Order
ENSBTAG00000016931
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt
TrEMBL F8VSE7 F8VXV5
UniProt Splice Variant
Entrez Gene 144455
UniGene Hs.416375
RefSeq NM_203394
HUGO HGNC:23820
OMIM 612046
CCDS CCDS9016
HPRD 10929
IMGT
EMBL AC025161 AC079030
GenPept
RNA Seq Atlas 144455

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca