Version 5.4
Homo sapiens Protein: GPR64
Summary
InnateDB Protein IDBP-49150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPR64
Protein Name G protein-coupled receptor 64
Synonyms EDDM6; HE6; TM7LN2;
Species Homo sapiens
Ensembl Protein ENSP00000353421
InnateDB Gene IDBG-49134 (GPR64)
Protein Structure
UniProt Annotation
Function Could be involved in a signal transduction pathway controlling epididymal function and male fertility.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Epididymis specific. Both subunits were associated with apical membranes of efferent ductule and proximal epididymal duct epithelia.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007283 spermatogenesis
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000203 GPS motif
IPR000832 GPCR, family 2, secretin-like
IPR017981 GPCR, family 2-like
PFAM PF01825
PF00002
PRINTS PR00249
PIRSF
SMART SM00303
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IZP9
PhosphoSite PhosphoSite-Q8IZP9
TrEMBL
UniProt Splice Variant
Entrez Gene 10149
UniGene Hs.146978
RefSeq NP_001073329
HUGO HGNC:4516
OMIM 300572
CCDS CCDS43921
HPRD 04040
IMGT
EMBL AF538954 AF539455 AF539456 AL732509 AL732578 AY143364 AY143365 AY143366 AY143367 AY148343 BC113979 X81892
GenPept AAI13980 AAN33056 AAN33064 AAN33065 AAN38971 AAN38972 AAN38973 AAN38974 AAN75702 CAA57479 CAI40668 CAI40669 CAI40670 CAI40671 CAI41675 CAI41676 CAI41677 CAI41678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca