InnateDB Protein
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IDBP-49323.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SYT1
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Protein Name
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synaptotagmin I
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Synonyms
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P65; SVP65; SYT;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000261205
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InnateDB Gene
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IDBG-49321 (SYT1)
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Protein Structure
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Function |
May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
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Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
28
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000008
C2 domain
IPR001565
Synaptotagmin
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PFAM |
PF00168
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PRINTS |
PR00360
PR00399
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
P21579
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PhosphoSite |
PhosphoSite-P21579
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TrEMBL |
F8W1U9
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UniProt Splice Variant |
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Entrez Gene |
6857
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UniGene |
Hs.713760
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RefSeq |
NP_005630
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HUGO |
HGNC:11509
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OMIM |
185605
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CCDS |
CCDS9017
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HPRD |
01710
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IMGT |
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EMBL |
AC027288
AC073570
AC073572
AC073606
AC073616
AC078917
AC090709
AK094616
AK126908
BC058917
CH471054
CR627387
M55047
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GenPept |
AAA60609
AAH58917
BAG52897
BAG54392
CAH10483
EAW97343
EAW97344
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