Homo sapiens Protein: LRPPRC | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-49389.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | LRPPRC | ||||||||||||||||||||||||||
Protein Name | leucine-rich PPR-motif containing | ||||||||||||||||||||||||||
Synonyms | CLONE-23970; GP130; LRP130; LSFC; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000260665 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-49387 (LRPPRC) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters. Binds single-stranded DNA (By similarity). {ECO:0000250}. | ||||||||||||||||||||||||||
Subcellular Localization | Mitochondrion. Nucleus, nucleoplasm. Nucleus inner membrane. Nucleus outer membrane. Note=Seems to be predominantly mitochondrial. | ||||||||||||||||||||||||||
Disease Associations | Leigh syndrome French-Canadian type (LSFC) [MIM:220111]: Severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency. In the Saguenay-Lac Saint Jean region of Quebec province in Canada, a biochemically distinct form of Leigh syndrome with COX deficiency has been described. Patients have been observed to have a developmental delay, hypotonia, mild facial dysmorphism, chronic well-compensated metabolic acidosis, and high mortality due to episodes of severe acidosis and coma. Enzyme activity was close to normal in kidney and heart, 50% of normal in fibroblasts and skeletal muscle, and nearly absent in brain and liver. LSFC patients show reduced (<30%) levels of LRPPRC in both fibroblast and liver mitochondria and a specifically reduced translation of COX subunits MT-CO1/COXI and MT-CO3 (COXIII). {ECO:0000269PubMed:12529507}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||||||
Tissue Specificity | Expressed ubiquitously. Expression is highest in heart, skeletal muscle, kidney and liver, intermediate in brain, non-mucosal colon, spleen and placenta, and lowest in small intestine, thymus, lung and peripheral blood leukocytes. {ECO:0000269PubMed:11827465, ECO:0000269PubMed:15139850}. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR002885
Pentatricopeptide repeat |
||||||||||||||||||||||||||
PFAM |
PF01535
PF12854 PF13041 PF13812 |
||||||||||||||||||||||||||
PRINTS | |||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||
SMART | |||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | P42704 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P42704 | ||||||||||||||||||||||||||
TrEMBL | E5KNY5 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 10128 | ||||||||||||||||||||||||||
UniGene | Hs.714050 | ||||||||||||||||||||||||||
RefSeq | NP_573566 | ||||||||||||||||||||||||||
HUGO | HGNC:15714 | ||||||||||||||||||||||||||
OMIM | 607544 | ||||||||||||||||||||||||||
CCDS | CCDS33189 | ||||||||||||||||||||||||||
HPRD | 06343 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AC108476 AC127379 AK125781 AK290016 AY289212 BC010282 BC026034 BC050311 BC130285 CH471053 HQ205426 HQ205427 HQ205428 HQ205429 HQ205430 HQ205431 HQ205432 HQ205433 HQ205434 HQ205435 HQ205436 HQ205437 HQ205438 HQ205439 HQ205440 HQ205441 HQ205442 HQ205443 HQ205444 HQ205445 HQ205446 HQ205447 HQ205448 HQ205449 HQ205450 HQ205451 HQ205452 HQ205453 HQ205454 HQ205455 HQ205456 HQ205457 HQ205458 HQ205459 HQ205460 HQ205461 HQ205462 HQ205463 HQ205464 HQ205465 M92439 | ||||||||||||||||||||||||||
GenPept | AAA67549 AAH10282 AAH26034 AAH50311 AAI30286 AAP41922 AAY24012 AAY24043 ADP90894 ADP90895 ADP90896 ADP90897 ADP90898 ADP90899 ADP90900 ADP90901 ADP90902 ADP90903 ADP90904 ADP90905 ADP90906 ADP90907 ADP90908 ADP90909 ADP90910 ADP90911 ADP90912 ADP90913 ADP90914 ADP90915 ADP90916 ADP90917 ADP90918 ADP90919 ADP90920 ADP90921 ADP90922 ADP90923 ADP90924 ADP90925 ADP90926 ADP90927 ADP90928 ADP90929 ADP90930 ADP90931 ADP90932 ADP90933 BAC86287 BAF82705 EAX00284 | ||||||||||||||||||||||||||