InnateDB Protein
|
IDBP-49454.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SMARCD3
|
Protein Name
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
|
Synonyms
|
BAF60C; CRACD3; Rsc6p;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000262188
|
InnateDB Gene
|
IDBG-49450 (SMARCD3)
|
Protein Structure
|
|
Function |
Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:14701856}.
|
Disease Associations |
|
Tissue Specificity |
Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
32
[view]
|
Protein-Protein |
32
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
10 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR003121
SWIB/MDM2 domain
IPR019835
SWIB domain
|
PFAM |
PF02201
|
PRINTS |
|
PIRSF |
|
SMART |
SM00151
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6STE5
|
PhosphoSite |
PhosphoSite-Q6STE5
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
6604
|
UniGene |
Hs.649478
|
RefSeq |
NP_001003801
|
HUGO |
HGNC:11108
|
OMIM |
601737
|
CCDS |
CCDS34780
|
HPRD |
03440
|
IMGT |
|
EMBL |
AC005486
AC021097
AY450430
AY450431
BC002628
BC110350
CH471173
U66619
|
GenPept |
AAC50697
AAH02628
AAI10351
AAR88510
AAR88511
AAS00380
AAS02031
EAW54005
EAW54007
EAW54008
|
|
|