InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PPM1B

Summary

InnateDB Protein

IDBP-49498.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPM1B

Protein Name

protein phosphatase, Mg2+/Mn2+ dependent, 1B

Synonyms

PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX;

Species

Homo sapiens

Ensembl Protein

ENSP00000282412

InnateDB Gene

IDBG-49488 (PPM1B)

Protein Structure

UniProt Annotation

Function

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269PubMed:18930133, ECO:0000269PubMed:22750291}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	50 [view]
Protein-Protein	49 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0030145	manganese ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006499	N-terminal protein myristoylation
GO:0019221	cytokine-mediated signaling pathway
GO:0032688	negative regulation of interferon-beta production
GO:0035970	peptidyl-threonine dephosphorylation
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050687	negative regulation of defense response to virus