InnateDB Protein
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IDBP-49502.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PPM1B
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Protein Name
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protein phosphatase, Mg2+/Mn2+ dependent, 1B
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Synonyms
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PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000326089
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InnateDB Gene
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IDBG-49488 (PPM1B)
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Protein Structure
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Function |
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269PubMed:18930133, ECO:0000269PubMed:22750291}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000269PubMed:22781750}. Membrane {ECO:0000250}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
50
[view]
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Protein-Protein |
49
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0006470
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protein dephosphorylation
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GO:0006499
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N-terminal protein myristoylation
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GO:0019221
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cytokine-mediated signaling pathway
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GO:0032688
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negative regulation of interferon-beta production
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GO:0035970
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peptidyl-threonine dephosphorylation
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GO:0042347
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negative regulation of NF-kappaB import into nucleus
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GO:0043124
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negative regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0050687
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negative regulation of defense response to virus
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Cellular Component |
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PDB ID |
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InterPro |
IPR012911
Protein serine/threonine phosphatase 2C, C-terminal
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PFAM |
PF07830
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75688
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PhosphoSite |
PhosphoSite-O75688
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
5495
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UniGene |
Hs.713776
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RefSeq |
NP_808908
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HUGO |
HGNC:9276
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OMIM |
603770
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CCDS |
CCDS1818
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HPRD |
04796
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IMGT |
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EMBL |
AC013717
AC019129
AF136972
AF294792
AJ005801
AJ271832
AJ271835
AL833035
BC012002
BC064381
CH471053
DQ023508
DQ023509
DQ023510
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GenPept |
AAG02232
AAG49433
AAH12002
AAH64381
AAX88954
AAY89639
AAY89640
AAY89641
CAA06704
CAC27992
CAC27993
CAH56319
EAX00282
EAX00283
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