Version 5.4
Homo sapiens Protein: HNRNPL
Summary
InnateDB Protein IDBP-49637.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPL
Protein Name heterogeneous nuclear ribonucleoprotein L
Synonyms hnRNP-L; HNRPL;
Species Homo sapiens
Ensembl Protein ENSP00000373401
InnateDB Gene IDBG-49631 (HNRNPL)
Protein Structure
UniProt Annotation
Function Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. {ECO:0000269PubMed:11809897}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000269PubMed:17289661}. Cytoplasm {ECO:0000269PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 93 [view]
Protein-Protein 91 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
Biological Process
Cellular Component
GO:0019013 viral nucleocapsid
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-P14866
TrEMBL B4DVF8
UniProt Splice Variant
Entrez Gene 3191
UniGene Hs.718661
RefSeq
HUGO HGNC:5045
OMIM 603083
CCDS
HPRD 04360
IMGT
EMBL AC008982 AK301062
GenPept BAG62670

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca