InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HNRNPL

Summary

InnateDB Gene

IDBG-49631.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRNPL

Gene Name

heterogeneous nuclear ribonucleoprotein L

Synonyms

hnRNP-L; HNRPL

Species

Homo sapiens

Ensembl Gene

ENSG00000104824

Encoded Proteins

IDBP-49633

heterogeneous nuclear ribonucleoprotein L

IDBP-49637

heterogeneous nuclear ribonucleoprotein L

IDBP-765113

IDBP-760732

IDBP-766149

IDBP-762731

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24371310

THRIL, a large intergenic noncoding RNA, binds to heterogenous nuclear ribonucleoprotein L (HNRNPL) and forms a functional THRIL-HNRNPL complex that regulates transcription of TNF by binding to its promoter.

Entrez Gene

Summary

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:38836388-38852347

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000221419	ENSP00000221419
ENST00000388749	ENSP00000373401
ENST00000600873	ENSP00000470231
ENST00000601813	ENSP00000469913
ENST00000595443
ENST00000595164
ENST00000600741
ENST00000595804
ENST00000597731
ENST00000598985
ENST00000601664
ENST00000601449	ENSP00000469349
ENST00000601047
ENST00000600233	ENSP00000472150

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	91 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0019013	viral nucleocapsid
GO:0030529	ribonucleoprotein complex
GO:0045120	pronucleus
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000015165

View Gene Order

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.644906 Hs.718661

RefSeq

NM_001005335 NM_001533

HUGO

OMIM

CCDS

CCDS33015 CCDS33016

HPRD

04360

IMGT

EMBL

GenPept

RNA Seq Atlas