InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MYF5

Summary

InnateDB Protein

IDBP-49659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYF5

Protein Name

myogenic factor 5

Synonyms

bHLHc2;

Species

Homo sapiens

Ensembl Protein

ENSP00000228644

InnateDB Gene

IDBG-49657 (MYF5)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0001502	cartilage condensation
GO:0001503	ossification
GO:0001756	somitogenesis
GO:0001952	regulation of cell-matrix adhesion
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0030198	extracellular matrix organization
GO:0035914	skeletal muscle cell differentiation
GO:0042692	muscle cell differentiation
GO:0042693	muscle cell fate commitment
GO:0043010	camera-type eye development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048644	muscle organ morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0051149	positive regulation of muscle cell differentiation
GO:0060415	muscle tissue morphogenesis