InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLL3

Summary

InnateDB Protein

IDBP-49773.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLL3

Protein Name

myeloid/lymphoid or mixed-lineage leukemia 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000347325

InnateDB Gene

IDBG-49771 (MLL3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	32 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008270	zinc ion binding
GO:0042800	histone methyltransferase activity (H3-K4 specific)
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035556	intracellular signal transduction
GO:0051568	histone H3-K4 methylation

Cellular Component

GO:0005634	nucleus
GO:0035097	histone methyltransferase complex

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR001594 Zinc finger, DHHC-type, palmitoyltransferase
IPR001841 Zinc finger, RING-type
IPR001965 Zinc finger, PHD-type
IPR003616 Post-SET domain
IPR003888 FY-rich, N-terminal
IPR003889 FY-rich, C-terminal
IPR009071 High mobility group box domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR019787 Zinc finger, PHD-finger

PFAM