InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTLA

Summary

InnateDB Protein

IDBP-49860.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTLA

Protein Name

B and T lymphocyte associated

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000333919

InnateDB Gene

IDBG-49858 (BTLA)

Protein Structure

UniProt Annotation

Function

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. {ECO:0000269PubMed:12796776}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0002768	immune response-regulating cell surface receptor signaling pathway
GO:0007166	cell surface receptor signaling pathway
GO:0030889	negative regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0042130	negative regulation of T cell proliferation
GO:0046642	negative regulation of alpha-beta T cell proliferation