Version 5.4
Homo sapiens Gene: BTLA
Summary
InnateDB Gene IDBG-49858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTLA
Gene Name B and T lymphocyte associated
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186265
Encoded Proteins
IDBP-49860
B and T lymphocyte associated
IDBP-49862
B and T lymphocyte associated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:112463968-112499561
Strand Reverse strand
Band q13.2
Transcripts
ENST00000334529 ENSP00000333919
ENST00000383680 ENSP00000373178
ENST00000474965
ENST00000496584
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0007166 cell surface receptor signaling pathway
GO:0030889 negative regulation of B cell proliferation
GO:0031295 T cell costimulation
GO:0042130 negative regulation of T cell proliferation
GO:0046642 negative regulation of alpha-beta T cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000052013
View Gene Order
Pathways
NETPATH
NetPath_12
BCR pathway
REACTOME
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.445162
RefSeq NM_001085357 NM_181780 XM_005247136
HUGO
OMIM
CCDS CCDS33819 CCDS43130
HPRD 06392
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca