Version 5.4
Homo sapiens Protein: BTLA
Summary
InnateDB Protein IDBP-49862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTLA
Protein Name B and T lymphocyte associated
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000373178
InnateDB Gene IDBG-49858 (BTLA)
Protein Structure
UniProt Annotation
Function Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response. {ECO:0000269PubMed:12796776}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0031295 T cell costimulation
Cellular Component
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z6A9
PhosphoSite PhosphoSite-Q7Z6A9
TrEMBL
UniProt Splice Variant
Entrez Gene 151888
UniGene Hs.445162
RefSeq NP_001078826
HUGO HGNC:21087
OMIM 607925
CCDS CCDS43130
HPRD 06392
IMGT
EMBL AC092894 AK131204 AY293286 AY599411 BC107091 BC107092 DQ198368
GenPept AAI07092 AAI07093 AAP44003 AAT44901 ABA54407 BAD18396

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca