Homo sapiens Protein: PAK4 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-49982.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PAK4 | ||||||||||||||||||||||
Protein Name | p21 protein (Cdc42/Rac)-activated kinase 4 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000351049 | ||||||||||||||||||||||
InnateDB Gene | IDBG-49980 (PAK4) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. {ECO:0000269PubMed:11278822, ECO:0000269PubMed:11313478, ECO:0000269PubMed:14560027, ECO:0000269PubMed:15660133, ECO:0000269PubMed:20507994, ECO:0000269PubMed:20631255, ECO:0000269PubMed:20805321}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:12356872}. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highest expression in prostate, testis and colon. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000095
CRIB domain IPR000719 Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00786
PF00069 PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||
SMART |
SM00285
SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O96013 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-O96013 | ||||||||||||||||||||||
TrEMBL | M0R2X4 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 10298 | ||||||||||||||||||||||
UniGene | Hs.20447 | ||||||||||||||||||||||
RefSeq | NP_005875 | ||||||||||||||||||||||
HUGO | HGNC:16059 | ||||||||||||||||||||||
OMIM | 605451 | ||||||||||||||||||||||
CCDS | CCDS12528 | ||||||||||||||||||||||
HPRD | 05675 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB032968 AC011443 AF005046 AJ011855 AK074728 AK294586 AK300632 AL834236 BC002921 BC011368 BC025282 BC034511 CH471126 | ||||||||||||||||||||||
GenPept | AAD01210 AAH02921 AAH11368 AAH25282 AAH34511 BAA86456 BAC11166 BAG57777 BAG62322 CAA09820 CAD38914 EAW56858 EAW56859 EAW56861 EAW56864 EAW56865 EAW56866 | ||||||||||||||||||||||