Version 5.4
Homo sapiens Protein: FBXO18
Summary
InnateDB Protein IDBP-50042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO18
Protein Name F-box protein, helicase, 18
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000355415
InnateDB Gene IDBG-50040 (FBXO18)
Protein Structure
UniProt Annotation
Function DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. {ECO:0000269PubMed:11956208}.Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. {ECO:0000269PubMed:11956208}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001934 positive regulation of protein phosphorylation
GO:0032508 DNA duplex unwinding
GO:0072429 response to intra-S DNA damage checkpoint signaling
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
IPR014016 UvrD-like Helicase, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00646
PF12937
PF13013
PF00580
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFZ0
PhosphoSite PhosphoSite-Q8NFZ0
TrEMBL Q66K33
UniProt Splice Variant
Entrez Gene 84893
UniGene Hs.498543
RefSeq NP_835363
HUGO HGNC:13620
OMIM 607222
CCDS CCDS7072
HPRD 06243
IMGT
EMBL AF380349 AF454502 AF456237 AK027381 AK027496 AK095343 AK315173 AL133069 AL137186 BC012762 BC032674 BC080629 BC110884 BC113377 CH471072
GenPept AAH12762 AAH32674 AAH80629 AAI10885 AAI13378 AAM73631 AAP97700 AAP97705 BAB55073 BAB55154 BAC04535 BAG37614 CAB61392 CAI41073 CAI41074 EAW86426 EAW86427

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca