Homo sapiens Gene: FBXO18
Summary
InnateDB Gene IDBG-50040.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO18
Gene Name F-box protein, helicase, 18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134452
Encoded Proteins
F-box protein, helicase, 18
F-box protein, helicase, 18
F-box protein, helicase, 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:5890203-5937594
Strand Forward strand
Band p15.1
Transcripts
ENST00000362091 ENSP00000355415
ENST00000379999 ENSP00000369335
ENST00000397269 ENSP00000380439
ENST00000470089
ENST00000462507
ENST00000469009
ENST00000494526
ENST00000460453
ENST00000489042
ENST00000475867
ENST00000461504
ENST00000485290
ENST00000496013
ENST00000479433
ENST00000470353
ENST00000481029
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0001934 positive regulation of protein phosphorylation
GO:0032508 DNA duplex unwinding
GO:0072429 response to intra-S DNA damage checkpoint signaling
GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.498543
RefSeq NM_001258452 NM_001258453 NM_032807 NM_178150 XM_006717516 XM_006717517
HUGO
OMIM
CCDS CCDS7072 CCDS7073 CCDS73064
HPRD 06243
IMGT
EMBL
GenPept
RNA Seq Atlas