InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPP6

Summary

InnateDB Protein

IDBP-50131.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPP6

Protein Name

dipeptidyl-peptidase 6

Synonyms

DPPX; VF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000367001

InnateDB Gene

IDBG-50125 (DPP6)

Protein Structure

UniProt Annotation

Function

May be involved in the physiological processes of brain function. Has no dipeptidyl aminopeptidase activity. May modulate the cell surface expression and the activity of the potassium channel KCND2. {ECO:0000269PubMed:15476821}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Disease Associations

Familial paroxysmal ventricular fibrillation 2 (VF2) [MIM:612956]: A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. {ECO:0000269PubMed:19285295}. Note=The disease is caused by mutations affecting the gene represented in this entry. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2.

Tissue Specificity

Expressed predominantly in brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0008239	dipeptidyl-peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0008219	cell death
GO:0019228	neuronal action potential
GO:0042391	regulation of membrane potential
GO:0043266	regulation of potassium ion transport
GO:1901379	regulation of potassium ion transmembrane transport
GO:1901381	positive regulation of potassium ion transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002469 Peptidase S9B, dipeptidylpeptidase IV N-terminal
IPR011659 WD40-like Beta Propeller
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF00930
PF07676

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P42658

PhosphoSite