Version 5.4
Homo sapiens Gene: DPP6
Summary
InnateDB Gene IDBG-50125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPP6
Gene Name dipeptidyl-peptidase 6
Synonyms DPPX; VF2
Species Homo sapiens
Ensembl Gene ENSG00000130226
Encoded Proteins
IDBP-50129
dipeptidyl-peptidase 6
IDBP-50131
dipeptidyl-peptidase 6
IDBP-293704
dipeptidyl-peptidase 6
IDBP-293688
dipeptidyl-peptidase 6
IDBP-387502
dipeptidyl-peptidase 6
IDBP-813689
dipeptidyl-peptidase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:153887097-154894285
Strand Forward strand
Band q36.2
Transcripts
ENST00000332007 ENSP00000328226
ENST00000377770 ENSP00000367001
ENST00000404039 ENSP00000385578
ENST00000406326 ENSP00000384393
ENST00000427557 ENSP00000397303
ENST00000462622
ENST00000496611
ENST00000471100
ENST00000481593
ENST00000478614
ENST00000493268
ENST00000484789
ENST00000488512
ENST00000479637
ENST00000480367
ENST00000619756 ENSP00000477855
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008219 cell death
GO:0019228 neuronal action potential
GO:0042391 regulation of membrane potential
GO:0043266 regulation of potassium ion transport
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901381 positive regulation of potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061576
View Gene Order
ENSBTAG00000021941
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.490684 Hs.551097 Hs.561765 Hs.609409 Hs.610283 Hs.703229
RefSeq NM_001039350 NM_001290253 NM_001936 NM_130797 XM_006715872
HUGO
OMIM
CCDS CCDS75682 CCDS75683 CCDS75684
HPRD 00525
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca