Version 5.4
Homo sapiens Protein: OTUD7A
Summary
InnateDB Protein IDBP-5015.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OTUD7A
Protein Name OTU domain containing 7A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000305926
InnateDB Gene IDBG-5011 (OTUD7A)
Protein Structure
UniProt Annotation
Function Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. {ECO:0000269PubMed:20622874, ECO:0000269PubMed:23827681}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0035871 protein K11-linked deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002653 Zinc finger, A20-type
IPR003323 Ovarian tumour, otubain
IPR009060 UBA-like
PFAM PF01754
PF02338
PRINTS
PIRSF
SMART SM00259
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TE49
PhosphoSite PhosphoSite-Q8TE49
TrEMBL H0YN66
UniProt Splice Variant
Entrez Gene 161725
UniGene
RefSeq NP_570971
HUGO HGNC:20718
OMIM 612024
CCDS CCDS10026
HPRD 12666
IMGT
EMBL AC021316 AC026951 AC079969 AC104266 AC104759 AJ430383 BC035668
GenPept AAH35668 CAD23047

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca