InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INSIG1

Summary

InnateDB Protein

IDBP-50275.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSIG1

Protein Name

insulin induced gene 1

Synonyms

CL-6; CL6;

Species

Homo sapiens

Ensembl Protein

ENSP00000344741

InnateDB Gene

IDBG-50271 (INSIG1)

Protein Structure

UniProt Annotation

Function

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth. {ECO:0000269PubMed:12202038, ECO:0000269PubMed:12535518, ECO:0000269PubMed:16168377, ECO:0000269PubMed:16399501, ECO:0000269PubMed:16606821}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:12202038}; Multi-pass membrane protein {ECO:0000269PubMed:12202038}.

Disease Associations

Tissue Specificity

Expressed in all tissues tested with highest expression in the liver. {ECO:0000269PubMed:12202038}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0006991	response to sterol depletion
GO:0008152	metabolic process
GO:0008203	cholesterol metabolic process
GO:0008283	cell proliferation
GO:0010894	negative regulation of steroid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0032933	SREBP signaling pathway
GO:0042472	inner ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0044281	small molecule metabolic process
GO:0045599	negative regulation of fat cell differentiation
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0060021	palate development
GO:0060363	cranial suture morphogenesis
GO:1901303	negative regulation of cargo loading into COPII-coated vesicle