Version 5.4
Homo sapiens Protein: MED29
Summary
InnateDB Protein IDBP-50292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED29
Protein Name mediator complex subunit 29
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000314343
InnateDB Gene IDBG-50290 (MED29)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269PubMed:15555573}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15555573}.
Disease Associations
Tissue Specificity Widely expressed in embryo and adult. {ECO:0000269PubMed:15555573}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 80 [view]
Protein-Protein 80 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR021018 Mediator complex, subunit Med29, metazoa
PFAM PF11568
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9NX70
TrEMBL B4DUA7
UniProt Splice Variant
Entrez Gene 55588
UniGene Hs.669756
RefSeq
HUGO HGNC:23074
OMIM 612914
CCDS CCDS33021
HPRD 13748
IMGT
EMBL AK000411 AK294667 AK297772 AK300563 AL137304 AY729650 BC019015 CH471126
GenPept AAH19015 AAU43732 BAA91147 BAG57835 BAG60118 BAG62269 CAB70687 EAW56884

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca