InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RHOQ

Summary

InnateDB Protein

IDBP-50387.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RHOQ

Protein Name

ras homolog gene family, member Q

Synonyms

ARHQ; HEL-S-42; RASL7A; TC10; TC10A;

Species

Homo sapiens

Ensembl Protein

ENSP00000238738

InnateDB Gene

IDBG-50385 (RHOQ)

Protein Structure

UniProt Annotation

Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. {ECO:0000269PubMed:15546864}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15546864}. Cell membrane {ECO:0000269PubMed:15546864}; Lipid-anchor {ECO:0000269PubMed:15546864}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005522	profilin binding
GO:0005525	GTP binding
GO:0032427	GBD domain binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0008360	regulation of cell shape
GO:0015031	protein transport
GO:0030866	cortical actin cytoskeleton organization
GO:0032869	cellular response to insulin stimulus
GO:0032956	regulation of actin cytoskeleton organization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046326	positive regulation of glucose import
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051491	positive regulation of filopodium assembly
GO:0090005	negative regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005884	actin filament
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF08477

PRINTS

PR00449
PR00328

PIRSF

SMART

SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt