InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TIMM50

Summary

InnateDB Protein

IDBP-50565.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMM50

Protein Name

translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000318115

InnateDB Gene

IDBG-50563 (TIMM50)

Protein Structure

UniProt Annotation

Function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body. {ECO:0000269PubMed:15044455}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000269PubMed:15044455, ECO:0000269PubMed:16008839}; Single-pass membrane protein {ECO:0000269PubMed:15044455, ECO:0000269PubMed:16008839}.Isoform 2: Nucleus speckle. Note=Nuclear and enriched in speckles with snRNPs.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level). {ECO:0000269PubMed:15044455, ECO:0000269PubMed:16008839}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005134	interleukin-2 receptor binding
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006470	protein dephosphorylation
GO:0006626	protein targeting to mitochondrion
GO:0007006	mitochondrial membrane organization
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0016021	integral component of membrane
GO:0016607	nuclear speck