InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SOCS5

Summary

InnateDB Protein

IDBP-50630.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SOCS5

Protein Name

suppressor of cytokine signaling 5

Synonyms

CIS6; Cish5; CISH6; SOCS-5;

Species

Homo sapiens

Ensembl Protein

ENSP00000305133

InnateDB Gene

IDBG-50628 (SOCS5)

Protein Structure

UniProt Annotation

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269PubMed:15590694}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0007259	JAK-STAT cascade
GO:0009968	negative regulation of signal transduction
GO:0016049	cell growth
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556	intracellular signal transduction
GO:0040008	regulation of growth
GO:0045087	innate immune response (InnateDB)
GO:0045627	positive regulation of T-helper 1 cell differentiation
GO:0045629	negative regulation of T-helper 2 cell differentiation