Version 5.4
Homo sapiens Gene: SOCS5
Summary
InnateDB Gene IDBG-50628.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS5
Gene Name suppressor of cytokine signaling 5
Synonyms CIS6; Cish5; CISH6; SOCS-5
Species Homo sapiens
Ensembl Gene ENSG00000171150
Encoded Proteins
IDBP-50630
suppressor of cytokine signaling 5
IDBP-240735
suppressor of cytokine signaling 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 15590694
SOCS4 and SOCS5 regulate EGFR signaling
Entrez Gene
Summary The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:46698952-46763129
Strand Forward strand
Band p21
Transcripts
ENST00000306503 ENSP00000305133
ENST00000394861 ENSP00000378330
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0007259 JAK-STAT cascade
GO:0009968 negative regulation of signal transduction
GO:0016049 cell growth
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0045087 innate immune response (InnateDB)
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037104
View Gene Order
ENSBTAG00000008987
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_16
IL4 pathway
REACTOME
KEGG
hsa04630
Jak-STAT signaling pathway pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt O75159
TrEMBL B4DL10
UniProt Splice Variant
Entrez Gene 9655
UniGene Hs.468426 Hs.620396
RefSeq NM_014011 NM_144949
HUGO HGNC:16852
OMIM 607094
CCDS CCDS1830
HPRD
IMGT
EMBL AB014571 AC020604 AF073958 AK290194 AK296796 AL136896 BC032862 CH471053
GenPept AAD40484 AAH32862 AAY24289 BAA31646 BAF82883 BAG59372 CAB66830 EAX00236 EAX00237
RNA Seq Atlas 9655

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca