Version 5.4
Homo sapiens Protein: LGALS13
Summary
InnateDB Protein IDBP-50715.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS13
Protein Name lectin, galactoside-binding, soluble, 13
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000221797
InnateDB Gene IDBG-50713 (LGALS13)
Protein Structure
UniProt Annotation
Function Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis. {ECO:0000269PubMed:10527825, ECO:0000269PubMed:19497882}.
Subcellular Localization
Disease Associations
Tissue Specificity Detected in adult and fetal spleen, fetal kidney, adult urinary bladder and placenta. Placental expression originates predominantly from the syncytiotrophoblast. {ECO:0000269PubMed:10527825, ECO:0000269PubMed:19497882}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004622 lysophospholipase activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006644 phospholipid metabolic process
GO:0006915 apoptotic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001079 Galectin, carbohydrate recognition domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00337
PRINTS
PIRSF
SMART SM00276
SM00908
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHV8
PhosphoSite PhosphoSite-
TrEMBL Q1M314
UniProt Splice Variant
Entrez Gene 29124
UniGene
RefSeq NP_037400
HUGO HGNC:15449
OMIM 608717
CCDS CCDS33024
HPRD 16375
IMGT
EMBL AF117383 AM259729 AY055826 BC066304 BC069312 CH471126 FJ613336 FJ613337 FJ613338
GenPept AAF22001 AAH66304 AAH69312 AAL09162 ACR09638 ACR09639 ACR09640 CAJ97436 EAW56910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca