Version 5.4
Homo sapiens Protein: UBE3C
Summary
InnateDB Protein IDBP-50775.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE3C
Protein Name ubiquitin protein ligase E3C
Synonyms HECTH2;
Species Homo sapiens
Ensembl Protein ENSP00000309198
InnateDB Gene IDBG-50773 (UBE3C)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. {ECO:0000269PubMed:11278995, ECO:0000269PubMed:12692129, ECO:0000269PubMed:16341092, ECO:0000269PubMed:16601690}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. {ECO:0000269PubMed:11278995, ECO:0000269PubMed:12692129, ECO:0000269PubMed:9575161}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000048 IQ motif, EF-hand binding site
IPR000569 HECT
IPR024072 Dihydrofolate reductase-like domain
PFAM PF00612
PF00632
PRINTS
PIRSF
SMART SM00015
SM00119
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15386
PhosphoSite PhosphoSite-Q15386
TrEMBL
UniProt Splice Variant
Entrez Gene 9690
UniGene Hs.711323
RefSeq NP_055486
HUGO HGNC:16803
OMIM 614454
CCDS CCDS34789
HPRD 15604
IMGT
EMBL AC004898 AC004975 BC014029 BC026241 CH236954 CH471149 D13635
GenPept AAD51453 AAH14029 AAH26241 BAA02799 EAL23922 EAX04568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca