InnateDB Protein
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IDBP-50781.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UBE3C
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Protein Name
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ubiquitin protein ligase E3C
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Synonyms
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HECTH2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000373755
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InnateDB Gene
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IDBG-50773 (UBE3C)
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Protein Structure
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Function |
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. {ECO:0000269PubMed:11278995, ECO:0000269PubMed:12692129, ECO:0000269PubMed:16341092, ECO:0000269PubMed:16601690}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. {ECO:0000269PubMed:11278995, ECO:0000269PubMed:12692129, ECO:0000269PubMed:9575161}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0000209
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protein polyubiquitination
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GO:0042787
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protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR024072
Dihydrofolate reductase-like domain
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15386
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PhosphoSite |
PhosphoSite-Q15386
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9690
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UniGene |
Hs.711323
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RefSeq |
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HUGO |
HGNC:16803
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OMIM |
614454
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CCDS |
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HPRD |
15604
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IMGT |
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EMBL |
AC004898
AC004975
BC014029
BC026241
CH236954
CH471149
D13635
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GenPept |
AAD51453
AAH14029
AAH26241
BAA02799
EAL23922
EAX04568
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