InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARAP3

Summary

InnateDB Protein

IDBP-50824.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARAP3

Protein Name

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000239440

InnateDB Gene

IDBG-50822 (ARAP3)

Protein Structure

UniProt Annotation

Function

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin. {ECO:0000269PubMed:11804589, ECO:0000269PubMed:15569923}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0016192	vesicle-mediated transport
GO:0030336	negative regulation of cell migration
GO:0032312	regulation of ARF GTPase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0035021	negative regulation of Rac protein signal transduction
GO:0035024	negative regulation of Rho protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR000198 Rho GTPase-activating protein domain
IPR001164 Arf GTPase activating protein
IPR001660 Sterile alpha motif domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00620
PF01412
PF00169
PF07647
PF00536

PRINTS

PR00405

PIRSF

SMART

SM00314
SM00324
SM00105
SM00454
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt