InnateDB Protein
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IDBP-50830.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PTRF
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Protein Name
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polymerase I and transcript release factor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000349541
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InnateDB Gene
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IDBG-50828 (PTRF)
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Protein Structure
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Function |
Plays an important role in caveolae formation and organization. Required for the sequestration of mobile caveolin into immobile caveolae. Termination of transcription by RNA polymerase I involves pausing of transcription by TTF1, and the dissociation of the transcription complex, releasing pre-rRNA and RNA polymerase I from the template. PTRF is required for dissociation of the ternary transcription complex. {ECO:0000269PubMed:18056712, ECO:0000269PubMed:18191225, ECO:0000269PubMed:19726876}.
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Subcellular Localization |
Membrane, caveola. Cell membrane {ECO:0000269PubMed:15242332, ECO:0000269PubMed:17026959}. Microsome {ECO:0000269PubMed:15242332, ECO:0000269PubMed:17026959}. Endoplasmic reticulum. Cytoplasm, cytosol. Mitochondrion {ECO:0000269PubMed:15242332, ECO:0000269PubMed:17026959}. Nucleus {ECO:0000269PubMed:15242332, ECO:0000269PubMed:17026959}. Note=Found at the surface of the caveolae. Also found in the plasma membrane, microsomal and cytosolic fractions and at a low level in the mitochondrial and nuclear fractions. Translocates to the cytoplasm from the caveolae upon insulin stimulation. CAV1 is necessary to recruit it to the cell membrane (By similarity). Co- localizes with CAV1 in lipid rafts in adipocytes. {ECO:0000250}.
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Disease Associations |
Congenital generalized lipodystrophy 4 (CGL4) [MIM:613327]: A disorder characterized by the association of congenital generalized lipodystrophy with muscular dystrophy and cardiac anomalies. Congenital generalized lipodystrophy is characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. {ECO:0000269PubMed:19726876, ECO:0000269PubMed:20684003}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
44
[view]
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Protein-Protein |
44
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006360
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transcription from RNA polymerase I promoter
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GO:0006361
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transcription initiation from RNA polymerase I promoter
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GO:0006363
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termination of RNA polymerase I transcription
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GO:0010467
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gene expression
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Cellular Component |
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PDB ID |
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InterPro |
IPR010310
Type VII secretion system ESAT-6-like
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PFAM |
PF06013
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6NZI2
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PhosphoSite |
PhosphoSite-Q6NZI2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
284119
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UniGene |
Hs.593320
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RefSeq |
NP_036364
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HUGO |
HGNC:9688
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OMIM |
603198
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CCDS |
CCDS11425
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HPRD |
04433
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IMGT |
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EMBL |
AF000421
AF312393
AK314389
BC004295
BC008849
BC066123
BC073759
CH471152
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GenPept |
AAC63404
AAG27093
AAH04295
AAH08849
AAH66123
AAH73759
BAG37014
EAW60828
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