InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FBL

Summary

InnateDB Protein

IDBP-50845.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBL

Protein Name

fibrillarin

Synonyms

FIB; FLRN; RNU3IP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000221801

InnateDB Gene

IDBG-50843 (FBL)

Protein Structure

UniProt Annotation

Function

S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239). {ECO:0000269PubMed:24352239}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000269PubMed:14583623, ECO:0000269PubMed:2026646, ECO:0000269PubMed:2414294, ECO:0000269PubMed:24352239}. Note=Fibrillar region of the nucleolus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.

Experimentally validated
Total	136 [view]
Protein-Protein	135 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0044822	poly(A) RNA binding
GO:1990259	histone-glutamine methyltransferase activity

Biological Process

GO:0001649	osteoblast differentiation
GO:0006364	rRNA processing
GO:0008033	tRNA processing
GO:0016074	snoRNA metabolic process
GO:0032259	methylation
GO:1990258	histone glutamine methylation

Cellular Component

GO:0001652	granular component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0015030	Cajal body
GO:0016020	membrane
GO:0031428	box C/D snoRNP complex
GO:0070062	extracellular vesicular exosome